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Dtnb

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Dtnb

This article is about the DTNB gene and protein. For the chemical substance, see Ellman's_reagent.
Dystrobrevin, beta
Identifiers
DTNB Gene
Orthologs
SpeciesHumanMouse

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.[1]

Function

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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