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Title: Dihexa  
Author: World Heritage Encyclopedia
Language: English
Subject: AVN-101, Galantamine, GTS-21, Rivanicline, Ispronicline
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
CAS Registry Number
PubChem CID:
Chemical data
Formula C27H44N4O5
Molecular mass 504.67 g·mol−1

Dihexa (also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a oligopeptide and angiotensin IV derived drug candidate that acts as a hepatocyte growth factor agonist and dramatically improves the cognitive function of rats with Alzheimer's-like mental impairment.[1][2][3][4][5][6][7][8][9][10] In bench assays using living nerve cells to monitor new neuronal connections, Harding, Wright and their colleagues found Dihexa to be seven orders of magnitude more powerful than BDNF, which has yet to be effectively developed for therapeutic use. In other words, it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa.[11]


  1. ^ Joseph W. Harding, John W. Wright, Caroline C. Benoist, Leen H. Kawas, Gary A. Wayman (3 December 2013). "Patent US 8598118 - Hepatocyte growth factor mimics as therapeutic agents". Retrieved 11 October 2015. 
  2. ^ Alene T McCoy, Caroline C Benoist, John W Wright, Leen H Kawas, Jyote Bule-Ghogare, Mingyan Zhu, Suzanne M Appleyard, Gary A Wayman, Joseph W Harding (October 2012). "Evaluation of metabolically stabilized angiotensin IV analogs as pro-cognitive/anti-dementia agents". The Journal of Pharmacology and Experimental Therapeutics.  
  3. ^ Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW (November 2014). "The Procognitive and Synaptogenic Effects of Angiotensin IV–Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System". The Journal of Pharmacology And Experiemental Thereapeutics 351 (2): 390–402.  
  4. ^ Caroline C. Benoist, John W. Wright, Mingyan Zhu, Suzanne M. Appleyard, Gary A. Wayman, Joseph W. Harding (October 2011). "Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle1-Angiotensin IV Analogs". The Journal of Pharmacology And Experiemental Thereapeutics 339 (1): 35–44.  
  5. ^ Phillip M. Uribe,Leen H. Kawas, Joseph W. Harding, Allison B. Coffin (January 2015). "Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure". Frontiers in Cellular Neuroscience.  
  6. ^ John W Wright, Joseph W. Harding (January 2015). "The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease". Journal of Alzheimer's Disease 45 (4): 985–1000.  
  7. ^ Richard Siller, Sebastian Greenhough, Elena Naumovska, Gareth J. Sullivan (May 2015). "Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells". Stem Cell Reports 4 (5): 939–952.  
  8. ^ "32. The Innovators: Designing Medicine's Holy Grail". KOMO News. 27 August 2015. Retrieved 11 October 2015. 
  9. ^ "Brain Connections in Alzheimer's Rebuilt with New Peptide". GEN News Highlights. 11 October 2015. Retrieved 11 October 2015. 
  10. ^ "Brain-Enhancing 'Smart Drugs' Are Going Commercial". VICE. 17 July 2014. Retrieved 11 October 2015. 
  11. ^ "Prospective Alzheimer's drug builds new brain cell connections, improves cognitive function of rats". ScienceDaily. 11 October 2012. Retrieved 11 October 2015. 

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