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Dihydropyrimidine dehydrogenase

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Title: Dihydropyrimidine dehydrogenase  
Author: World Heritage Encyclopedia
Language: English
Subject: DPD, Pharmacogenetics
Publisher: World Heritage Encyclopedia

Dihydropyrimidine dehydrogenase

dihydropyrimidine dehydrogenase
Symbol DPYD
Entrez HUGO OMIM RefSeq EC number Locus p22

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.

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