World Library  
Flag as Inappropriate
Email this Article

Douglas Melton

Article Id: WHEBN0018793131
Reproduction Date:

Title: Douglas Melton  
Author: World Heritage Encyclopedia
Language: English
Subject: Lexington, Massachusetts, Michael J. Sandel
Publisher: World Heritage Encyclopedia

Douglas Melton

Douglas A. Melton
Born September 26, 1953
Fields Stem cell biology, Developmental biology
Institutions Harvard Stem Cell Institute
Harvard University
Howard Hughes Medical Institute
National Academy of Sciences
Alma mater

University of Illinois, B.S. Cambridge University, B.A.

Cambridge University, Ph.D.
Doctoral advisor John Gurdon
Notable awards George Ledlie Prize
Richard Lounsbery Award
Eliot P. Joslin Medal
Marshall Scholarship

Douglas A. Melton is the Xander University Professor at Harvard University, and an investigator at the Howard Hughes Medical Institute. Additionally, Melton serves as the co-director of the Harvard Stem Cell Institute and the co-chair of the Harvard University Department of Stem Cell and Regenerative Biology.

Melton serves on the Scientific Advisory Board of the Genetics Policy Institute, holds membership in the National Academy of the Sciences, and is a founding member of the International Society for Stem Cell Research.

Under a Marshall Scholarship, Melton did his PhD under John Gurdon at the University of Cambridge. Melton's early work in the 1980s pioneered the technique of in vitro transcription.[1] This later shifted to general developmental biology research in Xenopus, and eventually in the mid-1990s, became centered on the development of the pancreas.

His current research interests include pancreatic developmental biology and the directed differentiation of human embryonic stem cells, particularly in pertinence to type 1 diabetes, which afflicts both his children.

In 2001 when President George W. Bush cut federal funding of embryonic stem cell research, Melton used private donations to create 17 published[2] stem cell lines and distribute them without charge to researchers around the world.

In 2007 and 2009, Melton was listed among Time Magazine's 100 Most Influential People in The World.

In August 2008, Melton's lab published successful in vivo reprogramming of adult mice exocrine pancreatic cells into insulin secreting cells which closely resembled endogenous islet beta cells of pancreas in terms of their size, shape, ultrastructure and essential marker genes.[3] Unlike producing beta cells from conventional embryonic stem cells or recently developed induced pluripotent stem cell (iPS) technique, Melton's unique method involved direct cell reprogramming of adult cell type (exocrine cell) into other adult cell type (beta cell) without reversion to a pluripotent stem cell state. His team used a specific combination of three transcription factors, Ngn3 (or Neurog3), Pdx1 and Mafa for such direct cell reprogramming to yield cells capable of secreting insulin and remodelling local vasculature in pancreas to counteract hyperglycemia and diabetes.


  • Time 100


External links

  • Human Embryonic Stem (HUES) Cell Collection
  • The Melton Laboratory
  • Doug Melton Faculty Webpage
  • 2 Melton children suffering juvenile diabetes, on which father works
  • Derivation of Human Embryonic Stem Cells by Immunosurgery
  • Doug Melton's Curriculum Vitae
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.