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EDA (gene)

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Title: EDA (gene)  
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Subject: EDA, Ectoderm, Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia, Tumor necrosis factors, TopoTarget
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EDA (gene)

Ectodysplasin A
PDB rendering based on 1rj7.
Available structures
PDB Ortholog search: RCSB
Identifiers
EDA Gene
RNA expression pattern

Ectodysplasin-A is a protein that in humans is encoded by the EDA gene.[1][2]

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.[2]

References

Further reading

External links

  • GeneReview/NIH/UW entry on Hypohidrotic Ectodermal Dysplasia




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