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Endocrine disease

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Title: Endocrine disease  
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Subject: Isolated 17,20-lyase deficiency, Hypothyroidism, Mild androgen insensitivity syndrome, Complete androgen insensitivity syndrome, Androgen insensitivity syndrome
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Endocrine disease

Endocrine disease
Classification and external resources
Major endocrine glands. (Male left, female on the right.) 1. Pineal gland 2. Pituitary gland 3. Thyroid gland 4. Thymus 5. Adrenal gland 6. Pancreas 7. Ovary 8. Testes
ICD-10 E00-E35
ICD-9 240-259
MeSH D004700

Endocrine diseases are disorders of the endocrine system. The branch of medicine associated with endocrine disorders is known as endocrinology.

Types of endocrine disease

Broadly speaking, endocrine disorders may be subdivided into three groups:[1]

  1. Endocrine gland hyposecretion (leading to hormone deficiency)
  2. Endocrine gland hypersecretion (leading to hormone excess)
  3. Tumours (benign or malignant) of endocrine glands

Endocrine disorders are often quite complex, involving a mixed picture of hyposecretion and hypersecretion because of the feedback mechanisms involved in the endocrine system. For example, most forms of hyperthyroidism are associated with an excess of thyroid hormone and a low level of thyroid stimulating hormone.[2]

List of endocrine diseases

Adrenal disorders

Glucose homeostasis disorders

Thyroid disorders

Calcium homeostasis disorders and Metabolic bone disease

Pituitary gland disorders

Posterior pituitary

Anterior pituitary

Sex hormone disorders

Tumours of the endocrine glands not mentioned elsewhere

See also separate organs

Endocrine emergencies

In endocrinology, medical emergencies include diabetic ketoacidosis, hyperosmolar hyperglycemic state, hypoglycemic coma, acute adrenocortical insufficiency, phaeochromocytoma crisis, hypercalcemic crisis, thyroid storm, myxoedema coma and pituitary apoplexy.[3]

Emergencies arising from decompensated pheochromocytomas or parathyroid adenomas are sometimes referred for emergency resection when aggressive medical therapies fail to control the patient's state, however the surgical risks are significant, especially blood pressure lability and the possibility of cardiovascular collapse after resection (due to a brutal drop in respectively catecholamines and calcium, which must be compensated with gradual normalization).[4][5] It remains debated when emergency surgery is appropriate as opposed to urgent or elective surgery after continued attempts to stabilize the patient, notably in view of newer and more efficient medications and protocols.[6][7][8]

See also


  1. ^ "Endocrine Disorders". webmd. 
  2. ^ "Diagnosing Hyperthyroidism: Overactivity of the Thyroid Gland". endocrineweb. 
  3. ^ Savage, M W; P Mah; A Weetman; J Newell-Price (1 September 2004). "Endocrine emergencies". Postgraduate Medical Journal 80 (947): 506–515.  
  4. ^ Brouwers, FM; Eisenhofer, G; Lenders, JW; Pacak, K (December 2006). "Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma.". Endocrinology and metabolism clinics of North America 35 (4): 699–724, viii.  
  5. ^ Tahim, AS; Saunders, J; Sinha, P (2010). "A parathyroid adenoma: benign disease presenting with hyperparathyroid crisis.". Case reports in medicine 2010: 596185.  
  6. ^ Newell, KA; Prinz, RA; Pickleman, J; Braithwaite, S; Brooks, M; Karson, TH; Glisson, S (August 1988). "Pheochromocytoma multisystem crisis. A surgical emergency.". Archives of surgery (Chicago, Ill. : 1960) 123 (8): 956–9.  
  7. ^ Scholten, A.; Cisco, R. M.; Vriens, M. R.; Cohen, J. K.; Mitmaker, E. J.; Liu, C.; Tyrrell, J. B.; Shen, W. T.; Duh, Q.-Y. (2 January 2013). "Pheochromocytoma Crisis Is Not a Surgical Emergency". Journal of Clinical Endocrinology & Metabolism 98 (2): 581–591.  
  8. ^ Phitayakorn, R; McHenry, CR (June 2008). "Hyperparathyroid crisis: use of bisphosphonates as a bridge to parathyroidectomy.". Journal of the American College of Surgeons 206 (3): 1106–15.  

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