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Estrogen receptor alpha (ER-α), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ER-α is encoded by the gene ESR1 (EStrogen Receptor 1).[1][2][3]
The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.[4] Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[5][6]
Coactivators of ER-α include:
Estrogen receptor alpha has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Dna, Eukaryote, Rna, Chromosome, Gene expression
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Breast cancer, Pfam, Protein Data Bank, Estrogen receptor alpha, Estrogen receptor beta
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