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Fasoracetam

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Title: Fasoracetam  
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Subject: Racetams, Racetam, Nootropics, Piracetam, Pyrrolidones
Collection: Amides, Nootropics, Piperidines, Pyrrolidones, Racetams
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Fasoracetam

Fasoracetam
Names
IUPAC name
(5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one
Identifiers
 Y
ChemSpider  Y
Jmol-3D images Image
Image
KEGG  Y
PubChem
Properties
C10H16N2O2
Molar mass 196.246 g/mol
Pharmacology
Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 Y  (: Y/N?)

Fasoracetam (NS-105, 5-oxo-D-prolinepiperidinamide monohydrate) is a research chemical of the racetam family.[1]


Effects

Fasoracetam appears to act as a GABAB receptor antagonist. It has been shown to block memory disruptions caused by Baclofen, a GABA B agonist.[2] Fasoracetam upregulates GABA B receptors after repeat dosing.[3]

Fasoracetam may act as a mGluR agonist and research into the efficacy for treating ADHD and cognitive impairment is currently being conducted.[4] [5]

Similar to Coluracetam, Fasoracetam enhances high affinity choline reuptake (HACU). [2]

References

  1. ^ "5-oxo-D-prolinepiperidinamide monohydrate - Compound Summary". Retrieved 21 July 2013. 
  2. ^ a b "Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.". 
  3. ^ "Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment.". 
  4. ^ "A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture.". 
  5. ^ http://www.research.chop.edu/forms/btob/Oct12BtoB.pdf


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