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Fossa ovalis (heart)

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Title: Fossa ovalis (heart)  
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Subject: Foramen ovale (heart), Heart, Fossa ovalis, Septum primum, Pulmonary circulation
Collection: Cardiology
Publisher: World Heritage Encyclopedia

Fossa ovalis (heart)

Fossa ovalis
Heart viewed from the front, with right atrium and right ventricle opened. Fossa ovalis is labeled in the right atrium.
Latin Fossa ovalis cordis
Precursor Foramen ovale
Anatomical terminology

The fossa ovalis is a depression in the right atrium of the heart, at the level of the interatrial septum, the wall between right and left atrium. The fossa ovalis is the remnant of a thin fibrous sheet that covered the foramen ovale during fetal development.


  • Function 1
    • Closure 1.1
  • Clinical significance 2
    • Tricuspid valve stenosis 2.1
    • Aneurysm 2.2
    • Patent foramen ovale 2.3
  • See also 3
  • References 4
  • External links 5


During fetal development, the foramen ovale allows blood to pass from the right atrium to the left atrium, bypassing the nonfunctional fetal lungs while the fetus obtains its oxygen from the placenta. A flap of tissue called the septum primum acts as a valve over the foramen ovale during that time. After birth, the introduction of air into the lungs causes the pressure in the pulmonary circulatory system to drop. This change in pressure pushes the septum primum against the atrial septum, closing the foramen.[1] The septum primum and atrial septum eventually fuse together to form a complete seal, leaving a depression called the fossa ovalis. By age two, about 75% of people have a completely sealed fossa ovalis. An unfused fossa ovalis is called a patent foramen ovale. Depending on the circumstances, a patent foramen ovale may be completely asymptomatic, or may require surgery.[1]The limbus of fossa ovalis (annulus ovalis) is the prominent oval margin of the fossa ovalis in the right atrium. It is most distinct above and at the sides of the fossa ovalis; below, it is deficient. A small slit-like valvular opening is occasionally found, at the upper margin of the fossa, leading upward beneath the limbus, into the left atrium; it is the remains of the fetal aperture the foramen ovale between the two atria.


Almost immediately after the infant is born, the foramen ovale and ductus arteriosus close. The major changes that are made by the body occur at the first breath (in the case of heart and lung functions) and up to weeks after birth (such as the liver's enzyme synthesis). The foramen ovale becomes the fossa ovalis as the foramen closes.[2] This enables respiration and circulation independent from the mother's.

With the child's first breath, the lung sends oxygenated blood to the left atrium. As a resulting pressure in the left atrium is higher than that of the right, and the increased pressure holds the interatrial flap (which covers the foramen ovale) shut, therefore closing the foramen ovale as well.[2] In normal development, the closed foramen ovale fuses with the interatrial wall. During the first breath, vasoconstriction causes the ductus arterious to close, and during adult years, tissue occludes what once was the ductus arterious, creating the ligamentum arteriosum.[3]

Clinical significance

Tricuspid valve stenosis

When the foramen does not close, blood can travel between the left and right atria, mixing oxygenated and deoxygenated blood. The foramen ovale usually shuts by age one.[4] Several problems can occur if the hole is left open. The right atrium may develop higher than normal pressure, which interferes with the blood's passage through the tricuspid valve, resulting in tricuspid valve stenosis. Tricuspid valve stenosis does not usually require treatment, though if the heart valves begin to malfunction, surgery may be needed.


Aneurysms can occur in adulthood if the foramen ovale does not closed correctly. An aneurysm happens when an artery becomes enlarged in a localized area due to weakening of the arterial wall.[5]

When this type of aneurysm occurs in the area of the fossa ovalis, an enlarged pouch is formed. This pouch can protrude into the right atrium or the left atrium. The cause of this aneurysm is the result of abnormal, increased pressure within the heart. Even if the foramen ovale does seal shut, an aneurysm may occur, usually on the side of the right atrium. If the aneurysm stretches too far, it can narrow the opening of the inferior vena cava.[6] This type of aneurysm can be a result of plaque build-up in the arteries from coronary heart disease, as well as diseases of the aortic valve or mitral valve. Surgery may be useful in helping to cope with the aneurysm.

Patent foramen ovale

If the atrial septum does not close properly, it leads to a patent foramen ovale (PFO). This type of defect generally works like a flap valve, opening during certain conditions of increased pressure in the chest, such as during strain while having a bowel movement, cough, or sneeze. With enough pressure, blood may travel from the right atrium to the left. If there is a clot in the right side of the heart, it can cross the PFO, enter the left atrium, and travel out of the heart and to the brain, causing a stroke. If the clot travels into a coronary artery it can cause a heart attack.[7]

See also


  1. ^ a b Hara, H; Virmani, R; Ladich, E; Mackey-Bojack, S; Titus, J; Reisman, M; Gray, W; Nakamura, M; Mooney, M; Poulose, A; Schwartz, RS (Nov 1, 2005). "Patent foramen ovale: current pathology, pathophysiology, and clinical status.". Journal of the American College of Cardiology 46 (9): 1768–76.  
  2. ^ a b Johnson, Donna. "What is the Fossa Ovalis?". Conjecture Corporation. Retrieved 16 March 2012. 
  3. ^ Dryden, Richard. "Respiratory system". Retrieved 16 April 2012. 
  4. ^ Love, Barry A. (2 November 2, 2010). "Pediatric Patent Foramen Ovale Atrial Septal Defects". Medscape Reference. WebMD. 
  5. ^ Shirani, J.; Zafari, A.M.; Roberts, W.C. (August 1995). "Morphologic features of fossa ovalis membrane aneurysm in the adult and its clinical significance.". Journal of the American College of Cardiology 26 (2): 466–71.  
  6. ^ Topaz, O.; Edwards, J.E.; Bojack-Mackey, S; Titus, J.L. (Jul–Aug 2003). "Aneurysm of fossa ovalis in adults: a pathologic study". Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology 12 (4): 219–25.  
  7. ^ "Patent Foramen Ovale". The Cleveland Clinic. Retrieved 15 April 15, 2012. 

External links

  • 1751842874 at GPnotebook
  • 637927483 at GPnotebook
  • Atlas image: ht_rt_atrium at the University of Michigan Health System – "Right atrium, internal structure, anterior view"
  • Diagram
  • Dissection photo
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