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GDNF family receptor alpha 1

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Title: GDNF family receptor alpha 1  
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Subject: Glial cell line-derived neurotrophic factor, RET proto-oncogene, List of A1 genes, proteins or receptors
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GDNF family receptor alpha 1

GDNF family receptor alpha 1
PDB rendering based on 1q8d.
Available structures
PDB Ortholog search: RCSB
Identifiers
GFRA1 Gene
RNA expression pattern

GDNF family receptor alpha-1 is a protein that in humans is encoded by the GFRA1 gene.[1][2]

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[3]

Interactions

GDNF family receptor alpha 1 has been shown to interact with Glial cell line-derived neurotrophic factor[4][5] and RET proto-oncogene.[5][6]

References

Further reading



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