Gpr183

G protein-coupled receptor 183
Identifiers
GPR183 Gene
RNA expression pattern

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[1]

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[2] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[1]

EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation; its expression decreases during germinal cell development due to BCL6--a transcription factor required in germinal center development. EBI2 must turn on to move B cells to the germinal center from the periphery, and must turn off for B cells to exit the germinal center and re-enter the periphery.[3] EBI2 is a receptor for oxysterols, the most potent activator being 7α,25-dihydroxycholesterol.[4]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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