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Title: Galeterone  
Author: World Heritage Encyclopedia
Language: English
Subject: Cyproterone acetate, Cyanoketone, Metyrapone, 20α,22R-Dihydroxycholesterol, Abiraterone acetate
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
Routes Oral
CAS number
ATC code ?
Chemical data
Formula C26H32N2O 
Mol. mass 388.25

Galeterone (TOK-001 or VN/124-1) is a novel antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer. It possesses a unique dual mechanism of action, acting as both an androgen receptor antagonist and an inhibitor of CYP17A1, an enzyme required for the biosynthesis of the androgens.[1] As of the second half of 2014, galeterone is in phase III clinical trials for castration-resistant prostate cancer.[2]

See also


  1. ^ Brawer MK (2008). "New treatments for castration-resistant prostate cancer: highlights from the 44th annual meeting of the american society of clinical oncology, may 30-june 3, 2008, chicago, IL". Rev Urol 10 (4): 294–6.  
  2. ^ Yahoo! Finance (2014). "Tokai Pharmaceuticals’ Reformulated Galeterone Demonstrates Robust PSA Reductions in Advanced Prostate Cancer Patients". 

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