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Growth-hormone-releasing hormone receptor

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Title: Growth-hormone-releasing hormone receptor  
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Growth-hormone-releasing hormone receptor

Growth hormone releasing hormone receptor
Available structures
PDB Ortholog search: RCSB
Identifiers
GHRHR Gene
RNA expression pattern

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.[1]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[2]

Ligands

Antagonists

References

Further reading

External links

  • IUPHAR GPCR Database – GHRH receptor
  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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