Hck

Hemopoietic cell kinase
PDB rendering based on 1ad5.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.10.2
RNA expression pattern

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.[1]

The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types, and belongs to the Src family of tyrosine kinases. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.[2]

Interactions

HCK has been shown to interact with BCR gene,[3][4] ELMO1,[5] Cbl gene,[6][7] RAS p21 protein activator 1,[8] RASA3,[8] Granulocyte colony-stimulating factor receptor,[9] ADAM15[10] and RAPGEF1.[11]

References

Further reading



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