World Library  
Flag as Inappropriate
Email this Article

Ifnar2

Article Id: WHEBN0014164528
Reproduction Date:

Title: Ifnar2  
Author: World Heritage Encyclopedia
Language: English
Subject: Interferon, Interferon type I, Interferon-alpha/beta receptor, STAT1, STAT2
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Ifnar2

Interferon (alpha, beta and omega) receptor 2
PDB rendering based on 1n6u.
Available structures
PDB Ortholog search: RCSB
Identifiers
IFNAR2 Gene
RNA expression pattern

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[1]

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[2]

Interactions

IFNAR2 has been shown to interact with STAT2,[3][4] STAT1,[3][5] GNB2L1[5][6] and IFNA2.[7]

References

Further reading



This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.