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Ibutamoren

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Ibutamoren

Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormone secretagogue,[1][2] mimicking the GH stimulating action of the endogenous hormone ghrelin.[3][4] It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.[5] It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults,[6][7][8] and human studies have shown it to increase both muscle mass and bone mineral density,[9][10] making it a promising therapy for the treatment of frailty in the elderly.[11][12] It also alters metabolism of body fat and so may have application in the treatment of obesity.[13][14]

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