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Title: Immunophilins  
Author: World Heritage Encyclopedia
Language: English
Subject: EC 5.2, Cis-trans isomerase, FKBP52, Ascomycin, Formyl peptide receptor
Publisher: World Heritage Encyclopedia


In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert [sic] between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as Sirolimus (earlier rapamycin), cyclosporine, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. This isomerase activity can be inhibited by immunosuppressive drugs.

See also

External links

  • Immunophilins at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "Plant immunophilins and signal transduction" at
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