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Iohexol

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Iohexol

Iohexol
Systematic (IUPAC) name
1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
Clinical data
AHFS/Drugs.com
Pregnancy
category
  • US: B (No risk in non-human studies)
Legal status
  • (Prescription only)
Routes of
administration
Intrathecal, intravascular, oral, intracavital, rectal
Pharmacokinetic data
Protein binding Low
Metabolism Nil
Biological half-life Variable
Excretion Renal, unchanged
Identifiers
CAS Registry Number  Y
ATC code V08
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  N
Chemical data
Formula C19H26I3N3O9
Molecular mass 821.138 g/mol
 N   

Iohexol is a contrast agent, sold under the trade name Omnipaque. It is available in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Omnipaque 350 is commonly used as a contrast agent during coronary angiography.

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.[1] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.[2]

References

  1. ^  
  2. ^ Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S.  

External links

  • Omnipaque (Iohexol) injection, solution


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