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Janus kinase 2

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Title: Janus kinase 2  
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Subject: Janus kinase, Prolactin, Polycythemia, Chromosomal translocation, Epidermal growth factor receptor, SH2 domain, Erythropoietin receptor, GRB2, PTPN11, Interleukin 15
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Janus kinase 2

Janus kinase 2
PDB rendering based on 2b7a.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.10.2
Orthologs
SpeciesHumanMouse

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). JAK2 signaling is activated downstream from the prolactin receptor.[1]

Loss of Jak2 is lethal by embryonic day 12 in mice.[2]

JAK2 orthologs [3] have been identified in all mammals for which complete genome data are available.

Clinical significance

JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in leukemia patients.[4][5] Jak - 2 kinase mutations were found to have a high correlation with abnormal heart defects in those of Southeast Asian descent carrying the PYFA gene. [4][5] Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.[6] This mutation, (V617F) a change of valine to phenylalanine at the 617 position, appears to render hematopoietic cells more sensitive to growth factors such as erythropoietin and thrombopoietin, because the receptors for these growth factors require JAK2 for signal transduction. An inhibitor of JAK2-STAT5, AZD1480, was pointed as having activity in primary and CRPC.[7]

Interactions

Janus kinase 2 has been shown to interact with:

Prolactin signals through JAK2 are dependent on STAT5, and on the RUSH transcription factors.[51]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)

Template:JAK-STAT signaling pathway

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