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John P. A. Ioannidis

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John P. A. Ioannidis

John P. A. Ioannidis (born 1965 in New York City) is a professor and chairman at the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine as well as adjunct professor at Tufts University School of Medicine and Professor of Medicine and Director of the Stanford Prevention Research Center at Stanford University School of Medicine.[1][2]

Biography

He was born in 1965 and raised in Athens, Greece. He was Valedictorian of his class at Athens College, graduating in 1984. He graduated first in his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He then did a fellowship at Tufts University for infectious disease.[3]

Ioannidis's 2005 paper "Why Most Published Research Findings Are False"[4] has been the most downloaded technical paper from the journal PLoS Medicine.[5] Statisticians Goodman and Greenland agreed that "many medical research findings are less definitive than readers suspect" but found major flaws in Ioannidis's methods, noting that Ioannidis (who did not collaborate with any statisticians on the article) appeared to have confused alpha level with p value and also built the assumption that most findings are likely to be false into his reasoning, thereby making his logic circular. Therefore Goodman and Greenland rejected Ioannidis' claim as unsupportable by the methods used.[6][7] Ioannidis has responded to this critique.[8] A profile of his work in this area appears in the November 2010 issue of The Atlantic.[9] The Atlantic article notes Ioannidis analyzed "49 of the most highly regarded research findings in medicine over the previous 13 years". In the paper Ionnaidis compared the 45 studies that claimed to have uncovered effective interventions with data from subsequent studies with larger sample sizes. 7 (16%) of the studies were contradicted and for 7 (16%) the effects were smaller than in the initial study. 31 (68%) studies remained either unchallenged or the findings could be replicated.[10]

See also

References

External links

  • John P. A. Ioannidis, MD, PhD, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center
  • Ioannidis John P. A., Department of Hygiene and Epidemiology, University of Ioannina School of Medicine
  • Szgene.org, meta-analytic database of schizophrenia gene studies of which Dr. Ioannidis helped create.
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