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L-687,384

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Title: L-687,384  
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Subject: Sigma-1 receptor, Ditolylguanidine, Dimemorfan, Berberine, Igmesine
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L-687,384

L-687,384
Systematic (IUPAC) name
1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code None
PubChem
ChemSpider  N
Chemical data
Formula C21H25N 
Mol. mass 291.429 g/mol
 N   

L-687,384 is a sigma receptor agonist, selective for the σ1 subtype,[1] as well as an NMDA antagonist.[2]


References

  1. ^ Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology 129 (3): 215–24.  
  2. ^ McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters 174 (2): 181–4.  


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