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Lilrb1

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Title: Lilrb1  
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Subject: Leukocyte immunoglobulin-like receptors, LILRA3, CD3 (immunology), CD79B, IL18R1
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Lilrb1

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

PDB rendering based on 1g0x.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez n/a
Ensembl n/a
UniProt n/a
RefSeq (mRNA) n/a
RefSeq (protein) n/a
Location (UCSC) n/a
PubMed search n/a

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.[1][2] This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

See also

References

  1. ^ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Sep 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity 7 (2): 273–82.  
  2. ^ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells". J Exp Med 186 (11): 1809–18.  
  3. ^ "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1". 

Further reading

External links

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