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Title: Lepirudin  
Author: World Heritage Encyclopedia
Language: English
Subject: ATC code B01, Direct thrombin inhibitor
Publisher: World Heritage Encyclopedia


Template:Drugbox Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor.

Brand name: Refludan, Generic: Lepirudin rDNA for injection.

Lepirudin is a recombinant hirudin[1] derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.

Lepirudin may be used as an anticoagulant when heparins (unfractionated or low-molecular-weight) are contraindicated because of heparin-induced thrombocytopenia. Bayer has announced that it will cease the production of lepirudin (Refludan) effective May 31, 2012.[2]


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