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Leukocyte receptor tyrosine kinase

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Title: Leukocyte receptor tyrosine kinase  
Author: World Heritage Encyclopedia
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Subject: Tyrosine kinase, RTK class III, Fyn-related kinase, PTK7, MST1R
Publisher: World Heritage Encyclopedia

Leukocyte receptor tyrosine kinase

Leukocyte receptor tyrosine kinase
Symbols  ; TYK1
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2] The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]


LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]


  1. ^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204.  
  2. ^ a b "Entrez Gene: LTK leukocyte tyrosine kinase". 
  3. ^ Lopes, Susana (2008). 
  4. ^ Kozutsumi, H; Toyoshima H; Hagiwara K; Yazaki Y; Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene (ENGLAND) 9 (10): 2991–8.  
  5. ^ Ueno, H; Honda H; Nakamoto T; Yamagata T; Sasaki K; Miyagawa K; Mitani K; Yazaki Y; Hirai H (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene (ENGLAND) 14 (25): 3067–72.  

Further reading

  • Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase.". Embo J. 10 (10): 2911–9.  
  • Krolewski JJ, Lee R, Eddy R, et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82.  
  • Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.". Nature 333 (6174): 672–6.  
  • Toyoshima H, Kozutsumi H, Maru Y, et al. (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8.  
  • Richard I, Broux O, Chiannilkulchai N, et al. (1995). "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27.  
  • Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.". Oncogene 9 (10): 2991–8.  
  • Kozutsumi H, Toyoshima H, Hagiwara K, et al. (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines.". Biochem. Biophys. Res. Commun. 190 (2): 674–9.  
  • Ueno H, Sasaki K, Kozutsumi H, et al. (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.". J. Biol. Chem. 271 (44): 27707–14.  
  • Snijders AJ, Ho SC, Haase VH, et al. (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.". J. Biol. Chem. 272 (2): 1297–301.  
  • Ueno H, Honda H, Nakamoto T, et al. (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.". Oncogene 14 (25): 3067–72.  
  • Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.". Protein Sci. 11 (10): 2326–34.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Li N, Nakamura K, Jiang Y, et al. (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.". Hum. Mol. Genet. 13 (2): 171–9.  

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