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Title: Licofelone  
Author: World Heritage Encyclopedia
Language: English
Subject: Non-steroidal anti-inflammatory drug
Publisher: World Heritage Encyclopedia


CAS number 156897-06-2 YesY
PubChem 133021
Jmol-3D images Image 1
Molecular formula C23H22ClNO2
Molar mass 379.879 g·mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Licofelone is a dual COX/LOX inhibitor[1][2] being considered as a treatment for osteoarthritis[3] and which is under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. It has passed the phase III trials.[4]


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