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Liver receptor homolog-1

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Liver receptor homolog-1

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3][4][5]

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.[6]

Interactions

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[7][8]

References

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Further reading

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