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Ludwig's angina


Ludwig's angina

Classification and external resources
Swelling in the submandibular area in a patient with Ludwig's angina.
ICD-10 K12.2
ICD-9 528.3
DiseasesDB 29336
MedlinePlus 001047
MeSH D008158

Ludwig's angina, otherwise known as angina ludovici, is a serious, potentially life-threatening cellulitis,[1] or connective tissue infection, of the floor of the mouth, usually occurring in adults with concomitant dental infections and if left untreated, may obstruct the airways, necessitating tracheotomy. It is named after the German physician, Wilhelm Friedrich von Ludwig who first described this condition in 1836.[2][3] Other names include "angina Maligna" and "Morbus Strangularis".

Ludwig's angina should not be confused with angina pectoris, which is also otherwise commonly known as "angina". The word "angina" comes from the Greek word ankhon, meaning "strangling", so in this case, Ludwig's angina refers to the feeling of strangling, not the feeling of chest pain, though there may be chest pain in Ludwig's angina if the infection spreads into the retrosternal space.

The life-threatening nature of this condition generally necessitates surgical management with involvement of critical care physicians such as those found in an intensive care unit.[4]


  • Causes 1
  • Symptoms and signs 2
  • Treatment 3
  • References 4


Dental infections account for approximately 80% of cases of Ludwig's angina.[5] Mixed infections, due to both aerobes and anaerobes, are of the cellulitis associated with Ludwig's angina. Typically, these include alpha-hemolytic streptococci, staphylococci and bacteroides groups.[5]

The route of infection in most cases is from infected lower molars or from pericoronitis, which is an infection of the gums surrounding the partially erupted lower (usually third) molars. Although the widespread involvement seen in Ludwig's usually develops in immunocompromised persons, it can also develop in otherwise healthy individuals. Thus, it is very important to obtain dental consultation for lower-third molars at the first sign of any pain, bleeding from the gums, sensitivity to heat/cold or swelling at the angle of the jaw.

There has been a single case reported where Ludwig's angina was thought to be caused by a recent tongue piercing.[6][7][8]

Symptoms and signs

True Ludwig's Angina is a cellulitic facial infection. The signs are bilateral (meaning both sides) lower facial swelling around the lower jaw and upper neck. This is because the infection has spread to involve the Submandibular, Sublingual and Submental spaces of the face.

Swelling of the Submandibular space, while externally is concerning the true danger lies in the fact that the swelling has also spread inwardly - compromising, or in effect narrowing the airway. Dysphagia (difficulty swallowing), Odynophagia (pain during swallowing) are symptoms that are typically seen and demand immediate attention.

The Sublingual and Submental spaces are anterior (beneath the middle and chin areas of the lower jaw) to the Submandibular space. Swelling in these areas can often push the floor of the mouth, including the tongue upwards and backwards - further compromising the airway.

Localisation of infection to the sublingual space is accompanied by swelling of structures in the floor of the mouth as well as the tongue being pushed upwards and backwards.[5]

Spread of infection to the submaxillary spaces is usually accompanied by signs of cellulitis rather than those of an abscess. Submental and submandibular regions are swollen and tender.

Additional symptoms include malaise, fever, dysphagia (difficulty swallowing), odynophagia (pain during swallowing)[5] and, in severe cases, stridor or difficulty breathing. There may also be varying degrees of trismus. Swelling of the submandibular and/or sublingual space is imminent.


Treatment involves appropriate antibiotic medications, monitoring and protection of the airway in severe cases, and, where appropriate, urgent maxillo-facial surgery and/or dental consultation to incise and drain the collections. The antibiotic of choice is from the penicillin group.

Incision and drainage of the abscess may be either intraoral or external. An intraoral incision and drainage procedure is indicated if the infection is localized to the sublingual space. External incision and drainage is performed if infection involves the perimandibular spaces.[5]

A nasotracheal tube is sometimes warranted for ventilation if the tissues of the mouth make insertion of an oral airway difficult or impossible.

In cases where the patency of the airway is compromised, skilled airway management is mandatory. Fiberoptic intubation is common.

Ludwig's angina is a life-threatening condition, and carries a fatality rate of about 5%.[9]


  1. ^ "Ludwig angina" at Dorland's Medical Dictionary
  2. ^ Ludwig's angina at Who Named It?
  3. ^ W. F. Von Ludwig. Über eine in neuerer Zeit wiederholt hier vorgekommene Form von Halsentzündung. Medicinisches Correspondenzblatt des Württembergischen ärztlichen Vereins, Stuttgart, 1836, 6: 21-25.
  4. ^ Rowe, Ollapallil. "Does surgical decompression in Ludwig's angina decrease hospital length of stay?". ANZ J Surg. Retrieved 2013-01-31. 
  5. ^ a b c d e Dhingra, PL; Dhingra, Shruti (2010) [1992]. Nasim, Shabina, ed. Diseases of Ear, Nose and Throat. Dhingra, Deeksha (5 ed.). New Delhi: Elsevier. pp. 277–278.  
  6. ^ Body Piercing: To What Depths? An Unusual Case and Review of Associated Problems. Plastic & Reconstructive Surgery. 115(3):50e-54e, March 2005. Williams, Andrew M. M.A., M.R.C.S.(Ed.); Southern, Stephen J. F.R.C.S.(Plast.)
  7. ^ Koenig, Laura M.; Carnes, Molly (1999). "Body Piercing: Medical Concerns with Cutting Edge-Fashion". Journal of General Internal Medicine 14 (6): 379–385.  
  8. ^ Zadik Yehuda, Becker Tal, Levin Liran (January 2007). "Intra-oral and peri-oral piercing". J Isr Dent Assoc 24 (1): 29–34, 83.  
  9. ^ Newlands C, Kerawala C (2010). Oral and maxillofacial surgery. Oxford: Oxford University Press. pp. 374–375.  
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