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MAFF (gene)

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MAFF (gene)

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
Identifiers
Symbols  ; U-MAF; hMafF
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription factor MafF is a protein that in humans is encoded by the MAFF gene.[1][2] The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.[2]

See also

References

  1. ^
  2. ^ a b

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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