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Title: Mafp  
Author: World Heritage Encyclopedia
Language: English
Subject: Diisopropyl fluorophosphate, Fatty acid amide hydrolase, Activity-based proteomics
Publisher: World Heritage Encyclopedia


Methoxy arachidonyl fluorophosphonate
PubChem 10429254
ChemSpider 8604682 YesY
Jmol-3D images Image 1
Molecular formula C21H36FO2P
Molar mass 370.5
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases.[1] It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.

See also

  • DIFP - diisopropyl fluorophosphate, a related inhibitor
  • IDFP - isopropyl dodecylfluorophosphonate, another related inhibitor with selectivity for FAAH and MAGL
  • Activity based probes


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