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Map2k4

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Subject: Mitogen-activated protein kinase, MAP kinase kinase kinase, C-Jun N-terminal kinases
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Map2k4

Mitogen-activated protein kinase kinase 4
3ALN.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.12.2
Orthologs
SpeciesHumanMouse

Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.[1]

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.[2]

Interactions

MAP2K4 has been shown to interact with FLNC,[3] MAPK8,[4][5][6][7][8] MAPK8IP3[9][10] and AKT1.[5]

References

Further reading



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