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Mark2

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Mark2

MAP/microtubule affinity-regulating kinase 2
PDB rendering based on 1y8g.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.11.1, 2.7.11.26
Orthologs
SpeciesHumanMouse

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.[1][2][3]

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.[3]

Interactions

MARK2 has been shown to interact with AKT1.[4]

References

Further reading

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