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Mesoridazine

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Title: Mesoridazine  
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Language: English
Subject: Thioridazine, Butaclamol, Acetophenazine, Gevotroline, Promazine
Collection: Phenothiazines, Piperidines, Sulfoxides
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Mesoridazine

Mesoridazine
Systematic (IUPAC) name
10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}- 2-methylsulfinyl- 10H-phenothiazine
Clinical data
Trade names Serentil
AHFS/Drugs.com
MedlinePlus
Pregnancy
category
  • US: C (Risk not ruled out)
Legal status
  • (Prescription only)
Routes of
administration
oral, intravenous
Pharmacokinetic data
Protein binding 4%
Metabolism Hepatic/Renal
Biological half-life 24 to 48 hours
Excretion Biliary and renal
Identifiers
CAS Registry Number  Y
ATC code N05
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Chemical data
Formula C21H26N2OS2
Molecular mass 386.576 g/mol
Physical data
Melting point 130 °C (266 °F)
Solubility in water insoluble mg/mL (20 °C)
 Y   

Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure.

It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects.

Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome.

Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1]

It currently appears to be unavailable worldwide.

References

  1. ^ [2]



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