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Mestranol

 

Mestranol

Mestranol
Systematic (IUPAC) name
3-Methoxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yn-17-ol
Clinical data
AHFS/Drugs.com
MedlinePlus
Identifiers
CAS Registry Number  Y
ATC code None
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  N
Synonyms (8S,9S,13S,14S,17S)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
Chemical data
Formula C21H26O2
Molecular mass 310.43 g/mol
 N   

Mestranol (INN, USAN, BAN, JAN) is a synthetic estrogen and the 3-methyl ether of ethinyl estradiol. It was used as the estrogen in many of the first oral contraceptives, and is still used today.

Mestranol is a biologically inactive prodrug of ethinyl estradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 µg of mestranol is pharmacokinetically bioequivalent to 35 µg of ethinyl estradiol).[1]

See also

References

  1. ^ Faigle, Johann W.; Schenkel, Lotte (1998). "Pharmacokinetics of estrogens and progestogens". In in Fraser, Ian S. (ed.). Estrogens and Progestogens in Clinical Practice. London: Churchill Livingstone. pp. 273–294.  



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