World Library  
Flag as Inappropriate
Email this Article

Metharbital

Article Id: WHEBN0003510987
Reproduction Date:

Title: Metharbital  
Author: World Heritage Encyclopedia
Language: English
Subject: Methylphenobarbital, Primidone, 3,3-Diethyl-2-pyrrolidinone, Etazepine, Carisbamate
Collection: Anticonvulsants, Barbiturates, Gabaa Receptor Positive Allosteric Modulators, Imides, Pyrimidinediones
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Metharbital

Metharbital
Systematic (IUPAC) name
5,5-Diethyl-1-methylpyrimidine-2,4,6(1H,3H,5H)-trione
Clinical data
AHFS/Drugs.com
Identifiers
CAS Registry Number  Y
ATC code N03
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEMBL  Y
Synonyms Endiemal, metharbitone, methobarbitone[1]
Chemical data
Formula C9H14N2O3
Molecular mass 198.219 g/mol
 Y   

Metharbital was patented in 1905 by Emil Fischer working for Merck.[2] It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.[3][4] It has similar properties to phenobarbital.

History

  • 1952 Gemonil was introduced by Abbott Laboratories.
  • 1990 Abbott stopped marketing.

Synthesis

Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.[5][6][7]

References

  1. ^ The Comparative Toxicogenomics Database: Metharbital
  2. ^ US Patent 782742
  3. ^ The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN 0-632-06046-8
  4. ^ The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5
  5. ^ A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949)
  6. ^ Snyder, J. A.; Link, K. P. (1953). "Preparation and Characterization by Alkaline Methanolysis of 5,5-Diethyl-4-(tetraacetyl-β-D-glucosyloxy)-2,6(1,5)-pyrimidinedione". Journal of the American Chemical Society 75 (8): 1881.  
  7. ^ U.S. Patent 782,742


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.