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Michael Smith (chemist)

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Title: Michael Smith (chemist)  
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Subject: Nobel Prize in Chemistry, Canadian Medical Hall of Fame, List of Nobel laureates by country, List of Nobel laureates by university affiliation, Peter Wall Institute for Advanced Studies
Collection: 1932 Births, 2000 Deaths, Alumni of the University of Manchester, British Emigrants to Canada, Businesspeople from Vancouver, Businesspeople in the Pharmaceutical Industry, Canadian Atheists, Canadian Biochemists, Canadian Company Founders, Canadian Geneticists, Canadian Medical Hall of Fame, Canadian Medical Researchers, Canadian Nobel Laureates, Companions of the Order of Canada, Fellows of the Royal Society, Members of the European Molecular Biology Organization, Members of the Order of British Columbia, Naturalized Citizens of Canada, Nobel Laureates in Chemistry, People Educated at Arnold School, People from Blackpool, University of British Columbia Faculty
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Michael Smith (chemist)

Michael Smith
Michael Smith
Born (1932-04-26)26 April 1932[1]
Blackpool, England
Died 4 October 2000(2000-10-04) (aged 68)
Vancouver, British Columbia, Canada
Nationality Canada
Fields Chemistry
Alma mater University of Manchester (BSc, PhD)
Thesis Studies in the stereochemistry of diols and their derivatives (1956)
Known for Site-directed mutagenesis
Notable awards

Michael Smith CC, OBC, FRS[2] (April 26, 1932 – October 4, 2000) was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry[3] with Kary Mullis for his work in developing site-directed mutagenesis. Following a PhD in 1956 from the University of Manchester,[4] he undertook postdoctoral research with Har Gobind Khorana (himself a Nobel Prize winner) at the British Columbia Research Council in Vancouver, Canada. Subsequently, Smith worked at the Fisheries Research Board of Canada Laboratory in Vancouver before being appointed a professor of biochemistry in the UBC Faculty of Medicine in 1966. Smith's career included roles as the founding director of the UBC Biotechnology Laboratory (1987 to 1995) and the founding scientific leader of the Protein Engineering Network of Centres of Excellence (PENCE). In 1996 he was named Peter Wall Distinguished Professor of Biotechnology. Subsequently he became the founding director of the Genome Sequencing Centre (now called the Genome Sciences Centre) at the BC Cancer Research Centre.


  • Education and early life 1
  • Career 2
    • Researcher 2.1
      • Site-specific Mutagenesis 2.1.1
    • Mentor 2.2
    • Administrator 2.3
      • Centre for Molecular Genetics 2.3.1
      • Biotechnology Laboratory and PENCE 2.3.2
      • Genome Sequence Centre 2.3.3
    • Commercial ventures 2.4
  • Awards and honours 3
  • References 4

Education and early life

Smith was born April 26, 1932, in [6]

Smith first attended St. Nicholas Church of England School, a state-run elementary school. At the time, few children from state schools in England went on to further academic education, however Smith did well in the [6][7]



Smith's research career began with a post-doctoral fellowship at the British Columbia Research Council under the supervision of Khorana, who was developing new techniques of synthesizing

  1. ^ a b c Hayden, Michael R.; Ling, Victor (2000). "Obituary: Michael Smith (1932–2000) Scientist who developed a landmark technique for gene analysis". Nature 408 (6814): 786–786.  
  2. ^ a b c d Astell, C. R. (2001). "Michael Smith. 26 April 1932 - 4 October 2000".  
  3. ^ Shampo, Marc A.; Kyle, Robert A. (2003). "Michael Smith—Canadian Biochemist Wins 1993 Nobel Prize". Mayo Clinic Proceedings 78 (7): 804.  
  4. ^ a b Smith, Michael (1956). Studies in the stereochemistry of diols and their derivatives. (PhD thesis). University of Manchester. 
  5. ^ a b c d e f g "No Ordinary Mike: Michael Smith, Nobel Laureate" C Astell and E. Damer, Ronsdale Press 2004 ISBN 1553800141
  6. ^ a b "Michael Smith Biographical". 
  7. ^ a b "Michael Smith, Canadian Chemist".  
  8. ^ Institute for Enzyme Research
  9. ^  
  10. ^ a b C. A. 3rd Hutchison, S. Phillips, M. H. Edgell, S. Gillam, P. Jahnke & M. Smith (1978). "Mutagenesis at a specific position in a DNA sequence".  
  11. ^ National Post August 16, 2006
  12. ^ "Earl W. Davie". American Society of Hematology. 
  13. ^ a b ZymoGenetics
  14. ^ Royal Bank Award
  15. ^ "Michael Smith: Organic Chemistry, Won the Nobel Prize in chemistry in 1993 for discovering site-directed mutagenesis". 
  16. ^ a b "Michael Smith Laboratories". University of British Columbia. 
  17. ^ Jacob Biely Faculty Research Prize
  18. ^ a b "Certificate of Election and Candidature: EC/1986/33, Michael Smith". London: The Royal Society. Archived from the original on 2015-08-25. 
  19. ^ UBC Killam Research Prize
  20. ^ Ernest C. Manning Awards
  21. ^ Hives, Christopher. "Michael Smith fonds" (PDF). Archived from the original (PDF) on 2015-07-03. Retrieved 9 December 2014. 
  22. ^ "Michael Smith Foundation for Health Research". 
  23. ^ "Faculty of Life Sciences, Michael Smith Building". University of Manchester. Archived from the original on 2015-06-27. 


His certificate of election to the Royal Society reads:

  • 2001 Michael Smith Foundation for Health Research founded[22]
  • 2004 UBC Biotechnology Laboratories was renamed the Michael Smith Laboratories[16]
  • 2004 Canada's Michael Smith Genome Sciences Centre named in his honour
  • 2004 University of Manchester named its new biological sciences research centre the Michael Smith Building[23]
  • 2005 Opening of the Smith-Yuen Apartments in Vancouver

Recognition of his achievements also included several honorary degrees.[5] The following are named in Smith's honour:

Smith received many awards in addition to the Nobel Prize, and was known for his generosity. He donated half of the Nobel Prize money to researchers working on the genetics of schizophrenia. The other half he gave to BC Science World and to the Society for Canadian Women in Science and Technology. He received the Royal Bank Award in 1999,[14] and donated the companion grant to the BC Cancer Foundation.[15][16]

Awards and honours

In 1981, Smith, ventured into the business world as a pharmaceutical entrepreneur. In collaboration with Professors Earl W. Davie[12] and Benjamin D. Hall of the University of Washington founded ZymoGenetics[13] in Seattle, Washington, US. The company began working on recombinant proteins in an international initiative with Novo Nordisk of Denmark. Recombinant DNA is used mostly in basic research. ZymoGenetics was acquired by Bristol-Myers Squibb.[13] Further applications of recombinant DNA are found in human and veterinary medicine, in agriculture, and in bioengineering.

Commercial ventures

Eventually, funding was secured from the BC Cancer Agency and in 1999 the Genome Sequence Centre was established with a mandate to develop and deploy genomics technologies in support of the life sciences, and in particular cancer research. The Genome Sciences Centre also provided technology to Genome Canada and Genome BC projects in the areas of human health, the environment, forestry, agriculture, and aquaculture.[11]

  • Identify all the approximately 20,000 – 25,000 genes in human DNA
  • Determine the sequences of the 3 billion chemical base pairs that make up human DNA
  • Store this information in databases
  • Improve tools for data analysis
  • Transfer related technologies to the private sector
  • Address the ethical, legal, and social issues (ELSI) that may arise from the project

Throughout the 1980s, Smith and his colleagues at the Canadian Institute for Advanced Research (CIAR) were interested in establishing a facility that would enable Canada to play a part in what had become known as the Human Genome Project, an international initiative whose goals were to:

Genome Sequence Centre

In 1987, the Biotechnology Laboratory, one of three provincial "Centres of Excellence" was established at UBC. The new facility subsumed the Centre for Molecular Genetics, and Smith became its director. He played an important role in drawing together scientists, and in writing the proposal for what would become the "Protein Engineering Network of Centres of Excellence" or PENCE.

Biotechnology Laboratory and PENCE

1982 Smith launched the Centre for Molecular Genetics in the Faculty of Medicine and became its director in 1986.

Centre for Molecular Genetics

  • 1981 UBC Senate (Faculty of Medicine elected representative)
  • Canadian Institute for Advanced Research (CIAR) Evolutionary Biology Program, Advisory Committee
  • Biotechnology Sector Committee of British Columbia
  • 1991 UBC Biomedical Research Centre, Interim Scientific Director

Smith was first and foremost a research chemist, but he understood the importance of sound administration in running an efficient, productive laboratory, and of participating in the process of decision making relating to funding and allocation of resources. He served his university and the wider academic community in many ways, including (but not limited to):


Smith knew that a productive laboratory depended on good graduate students, post-doctoral fellows and technicians to carry out the practical aspects of his work. He encouraged talented scientists from diverse backgrounds and challenged them to work independently.[5]


The team's paper describing site-directed mutagenesis was published as "Mutagenesis at a Specific Position in a DNA Sequence" in the Journal of Biological Chemistry in 1978.[10] For the team's work in developing oligonucleotide-directed site-directed mutagenesis, Smith shared the 1993 Nobel Prize in Chemistry with Kary Mullis, the inventor of Polymerase Chain Reaction.

The new technology enabled rapid identification and deliberate alteration of genes for the purpose of changing the characteristics of an organism. It raised the level of possibility of new diagnostic strategies and new treatments for genetic diseases, and even creation of novel artificial forms of life, as the progenitor technique for Polymerase Chain Reaction (PCR), Site-Directed Mutagenesis and Synthetic Biology.

In the late 1970s, Smith was concentrating exclusively on projects in molecular biology and how the genes within the DNA molecule act as reservoirs and transmitters of biological information. In 1978, Smith, in collaboration with former Fred Sanger lab sabbatical colleague Clyde A. Hutchison III,[10] introduced a new technique known as "oligonucleotide-directed site-directed mutagenesis" into molecular biology, resolving the problem of how to efficiently determine the effect of a single mutant gene. They developed a synthetic DNA technique for introducing site-specific mutations into genes. This permitted comparison of different protein molecules, revealing the role of the initial mutation.

Site-specific Mutagenesis

Smith then investigated the creation of mutations of any site within a viral genome. If possible, then the result could be an efficient method to engineer heritable changes in genes. His team experimented, finally, in 1977, confirming Smith's theory.[5]

Concurrently with conducting research for FRB, Smith held the positions of associate professor at the University of British Columbia's (UBC) Department of Biochemistry and honorary professor in the Department of Zoology. In 1966, Smith was appointed a research associate of the genes and genomes and methods of sequencing large DNA molecules. He returned from England as one of the world's leading molecular biologists.

After a few months in Wisconsin, Smith was ready for a new challenge; he returned to Vancouver as a senior scientist and head of the Chemistry Division with the Vancouver Technological Station of the Fisheries Research Board (FRB) of Canada. In this role he conducted studies on the feeding habits and survival of spawning salmon, as well as identification of olfactory stimuli guiding salmon to their birth stream. His main research interest, however, continued to be nucleic acid synthesis, for which he received a United States Public Health Service Research Grant.

, Smith moved with him. University of Wisconsin–Madison at the [8]

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