This article will be permanently flagged as inappropriate and made unaccessible to everyone. Are you certain this article is inappropriate? Excessive Violence Sexual Content Political / Social
Email Address:
Article Id: WHEBN0008250177 Reproduction Date:
In the hippocampus, granule cells of the dentate gyrus form distinctive unmyelinated axons that project along the mossy fiber pathway to the Cornu Ammonis area 3 (CA3). The axons emerge from the basal portions of the granule cells and pass through the hilus (or polymorphic cell layer) of the dentate gyrus before entering the stratum lucidum of CA3. Granule cell synapses tend to be glutamatergic (e.g. excitatory), though immunohistological data has indicated that some synapses contain neuropeptidergic elements including opiate peptides such as dynorphin and enkephalin. Moreover, there is growing evidence for co-localization of GABAergic and glutamatergic neurotransmitters within mossy fiber terminals, though the functional consequence of this co-localization is unclear.[2]
The pathway was so named by Ramon y Cajal because the axons display varicosities all along their lengths, giving them a "mossy" appearance. These mossy fibers form multiple synapses with the elaborate dendritic spines of CA3 pyramidal cells in stratum lucidum. These complex spines are known as "thorny excrescences". It has also been shown that the axons of granule cells synapse with a wide variety of inhibitory GABAergic interneurons in the hilar region of the dentate gyrus before continuing on to innervate pyramidal cells in the CA3 region. A single mossy fiber projection may make as many as 37 contacts with a single pyramidal cell, but innervates only about a dozen different pyramidal cells. In contrast, a single CA3 pyramidal cell receives input from about 50 different granule cells. It has been shown in rodents that the size of the mossy fiber projections can show large interindividual variations, which are to a large part heritable.[3] In addition, these variations show strong correlations with different types of behavior, mainly, but not exclusively, spatial learning.[4]
The synapses of the mossy fibers contain zinc, which can be stained specifically with a Timm staining.[5]
Mossy fiber (cerebellum), which shares little similarity with its hippocampal namesake.
Brain, Psychology, Basal ganglia, Neuroscience, Grey matter
Brodmann area 6, Latin, Hippocampus, Memory, Basal ganglia
Gaba, Acetylcholine, Anatomical terms of neuroanatomy, Perforant path, Entorhinal cortex
Cerebellum, Spinal cord, Climbing fiber, Inferior olivary nucleus, Parallel fiber
France, Paris, Behavioural genetics, Radboud University Nijmegen, University of Massachusetts Medical School
Neuroscience, Human brain, Spinal cord, Drosophila melanogaster, Psychiatry