World Library  
Flag as Inappropriate
Email this Article

Motor neuron disease

Article Id: WHEBN0000000876
Reproduction Date:

Title: Motor neuron disease  
Author: World Heritage Encyclopedia
Language: English
Subject: Progressive bulbar palsy, Pseudobulbar palsy, Amyotrophic lateral sclerosis, Exosome complex, Motor neurone disease
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Motor neuron disease

Motor neuron disease
spinal diagram
Classification and external resources
Specialty Neurology
ICD-10 G12.2
ICD-9-CM 335.2
DiseasesDB 8358
MeSH D016472

A motor neuron disease (MND) is any of five neurological disorders that selectively affect motor neurons, the cells that control voluntary muscles of the body. These five conditions are amyotrophic lateral sclerosis, primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy and pseudobulbar palsy.[1] They are neurodegenerative in nature and cause increasing disability and, eventually, death.[2]

Terminology

Technically the term "motor neuron disease" includes five diseases: amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy and pseudobulbar palsy.[1]

In the United States the term is often used interchangeably with ALS.[1] In the United Kingdom "motor neurone disease" may be used to mean ALS.

While MND refers to a specific subset of similar diseases, there are numerous other diseases of motor neurons that are referred to collectively as "motor neuron disorders", for instance disease belonging to spinal muscular atrophies.[2] However, they are not classified as "motor neuron diseases" by the tenth International Statistical Classification of Diseases and Related Health Problems (ICD-10) which is the definition followed in this article.

Classification

Motor neuron diseases affect either upper motor neurons (UMN) or lower motor neurons (LMN), or both:

Type UMN degeneration LMN degeneration
Amyotrophic lateral sclerosis (ALS) Yes Yes
Primary lateral sclerosis (PLS) Yes No
Progressive muscular atrophy (PMA) No Yes
Progressive bulbar palsy (PBP) No Yes, bulbar region
Pseudobulbar palsy Yes, bulbar region No

References

  1. ^ a b c
  2. ^ a b

External links

  • Motor neuron diseases at NINDS
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.