Muscarinic acetylcholine receptor M5

Cholinergic receptor, muscarinic 5

Identifiers

CHRM5 Gene

Gene Ontology
Molecular function	• G-protein coupled acetylcholine receptor activity
Cellular component	• postsynaptic membrane
Biological process	• regulation of phospholipase C activity
Sources: QuickGO

RNA expression pattern

The human muscarinic acetylcholine receptor M₅, encoded by the cyclic AMP levels and downregulate the activity of protein kinase A (PKA).

Contents

1 Ligands

1.1 Agonists

1.2 Positive allosteric modulators

1.3 Antagonists

2 See also

3 References

4 Further reading

Ligands

No highly selective agonists or antagonists for the M₅ receptor have been discovered as of 2009, but several non-selective muscarinic agonists and antagonists have significant affinity for M₅.

Agonists

Milameline ((E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde-O-methyloxime, CAS# 139886-32-1)

Sabcomeline

Positive allosteric modulators

VU-0238429: EC₅₀ = 1.16 μM; >30-fold selectivity versus M1 and M3, inactive at M2 and M4.^[1]

Antagonists

Xanomeline^[2]

See also

Muscarinic acetylcholine receptor

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v
t
e
Cell surface receptor: G protein-coupled receptors
Class A:
Rhodopsin like
Neurotransmitter
Adrenergic

α1 (A

B

D)

α2 (A

B

C)

β1

β2

β3

Purinergic

Adenosine (A1

A2A

A2B

A3)

P2Y (1

2

4

5

6

8

9

10

11

12

13

14)

Serotonin

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

5-HT2 (A

B

C)

5-HT (4

5A

6

7)

Other

Acetylcholine (M1

M2

M3

M4

M5)

Dopamine (D1

D2

D3

D4

D5)

Histamine (H1

H2

H3

H4)

Melatonin (1A

1B

1C)

TAAR (1

2

3

5

6

8

9)

Metabolites and
signaling molecules
Eicosanoid

CysLT (1

2)

LTB4 (1

2)

FPRL1

OXE

Prostaglandin (DP (1

2), EP (1

2

3

4), FP)

Prostacyclin

Thromboxane

Other

Bile acid

Cannabinoid (CB1

CB2, GPR (18

55

119))

EBI2

Estrogen

Free fatty acid (1

2

3

4)

Lactate

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Niacin (1

2)

Oxoglutarate

PAF

Sphingosine-1-phosphate (1

2

3

4

5)

Succinate

Peptide
Neuropeptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

Neurotensin (1

2)

Other

Anaphylatoxin (C3a

C5a)

Angiotensin (1

2)

Apelin

Bombesin (BRS3

GRPR

NMBR)

Bradykinin (B1

B2)

Chemokine

Cholecystokinin (A

B)

Endothelin (A

B)

Formyl peptide (1

2

3)

FSH

Galanin (1

2

3)

GHB receptor

Gonadotropin-releasing hormone (1

2)

Ghrelin

Kisspeptin

Luteinizing hormone/choriogonadotropin

MAS (1

1L

D

E

F

G

X1

X2

X3

X4)

Melanocortin (1

2

3

4

5)

MCHR (1

2)

Motilin

Opioid (Delta

Kappa

Mu

Nociceptin & Zeta, but not Sigma)

Orexin (1

2)

Oxytocin

Prokineticin (1

2)

Prolactin-releasing peptide

Relaxin (1

2

3

4)

Somatostatin (1

2

3

4

5)

Tachykinin (1

2

3)

Thyrotropin

Thyrotropin-releasing hormone

Urotensin-II

Vasopressin (1A

1B

2)

Miscellaneous
Orphan

GPR (1

3

4

6

12

15

17

18

19

20

21

22

23

25

26

27

31

32

33

34

35

37

39

42

44

45

50

52

55

61

62

63

65

68

75

77

78

81

82

83

84

85

87

88

92

101

103

109A

109B

119

120

132

135

137B

139

141

142

146

148

149

150

151

152

153

160

161

162

171

173

174

176

177

182

183)

Other

Adrenomedullin

Olfactory

Opsin (3

4

5

1LW

1MW

1SW

RGR

RRH)

Protease-activated (1

2

3

4)

SREB (1

2

3)

Class B: Secretin like
Orphan

GPR (56

64

97

98

110

111

112

113

114

115

116

123

124

125

126

128

133

143

144

155

157)

Other

Brain-specific angiogenesis inhibitor (1

2

3)

Cadherin (1

2

3)

Calcitonin

CALCRL

CD97

Corticotropin-releasing hormone (1

2)

EMR (1

2

3)

Glucagon (GR

GIPR

GLP1R

GLP2R)

Growth hormone releasing hormone

PACAPR1

GPR

Latrophilin (1

2

3

ELTD1)

Methuselah-like proteins

Parathyroid hormone (1

2)

Secretin

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic
glutamate / pheromone
Taste

TAS1R (1

2

3)

TAS2R (1

3

4

5

7

8

9

10

13

14

16

19

20

30

31

38

39

40

41

42

43

45

46

50

60)

Other

Calcium-sensing receptor

GABA B (1

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

GPRC6A

GPR (156

158

179)

RAIG (1

2

3

4)

Class F:
Frizzled / Smoothened
Frizzled

Frizzled (1

2

3

4

5

6

7

8

9

10)

Smoothened

Smoothened

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Muscarinic acetylcholine receptor M5

Muscarinic acetylcholine receptor M5

Contents

Ligands

Agonists

Positive allosteric modulators

Antagonists

See also

References

Further reading

Suggestions

Clozapine

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Acetylcholine receptor

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Amitriptyline

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