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N-Phenethyl-14-ethoxymetopon

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Title: N-Phenethyl-14-ethoxymetopon  
Author: World Heritage Encyclopedia
Language: English
Subject: List of opioids, Δ-opioid receptor, Kobret, 6β-Naltrexol-d4, Hemorphin
Collection: Delta-Opioid Agonists, Ethers, Ketones, Morphinans, Mu-Opioid Agonists, Phenols, Semisynthetic Opioids
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N-Phenethyl-14-ethoxymetopon

N-Phenethyl-14-ethoxymetopon
Systematic (IUPAC) name
(5α)-14-Ethoxy-3-hydroxy-5-methyl-17-(2-phenylethyl)-4,5-epoxymorphinan-6-one
Identifiers
CAS Registry Number  YesY
PubChem CID:
Chemical data
Formula C27H31NO4
Molecular mass 433.538 g/mol
 YesY   

N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.[1]

N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.[2]

See also

References

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