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Title: Nt5e  
Author: World Heritage Encyclopedia
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Subject: CD1A, CD153, CD320, NKG2, CD109
Collection: Clusters of Differentiation
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5'-nucleotidase, ecto (CD73)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CALJA; CD73; E5NT; NT; NT5; NTE; eN; eNT
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (Cluster of Differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.[1] CD73 commonly serves to convert AMP to adenosine.


  • Function 1
  • See also 2
  • References 3
  • Further reading 4
  • External links 5


Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

  • Resta R, Thompson LF (1997). "T cell signalling through CD73.". Cell. Signal. 9 (2): 131–9.  
  • Kirchhoff C, Hale G (1997). "Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.". Mol. Hum. Reprod. 2 (3): 177–84.  
  • Resta R, Yamashita Y, Thompson LF (1998). "Ecto-enzyme and signaling functions of lymphocyte CD73.". Immunol. Rev. 161: 95–109.  
  • Rosi F, Carlucci F, Marinello E, Tabucchi A (2002). "Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia.". Biomed. Pharmacother. 56 (2): 100–4.  
  • Babiychuk EB, Draeger A (2006). "Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?". Biochem. Soc. Trans. 34 (Pt 3): 374–6.  
  • Stefanovic V, Mandel P, Rosenberg A (1976). "Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells.". J. Biol. Chem. 251 (13): 3900–5.  
  • Thomson LF, Ruedi JM, Glass A, et al. (1990). "Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73).". Tissue Antigens 35 (1): 9–19.  
  • Klemens MR, Sherman WR, Holmberg NJ, et al. (1990). "Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.". Biochem. Biophys. Res. Commun. 172 (3): 1371–7.  
  • Boyle JM, Hey Y, Guerts van Kessel A, Fox M (1989). "Assignment of ecto-5'-nucleotidase to human chromosome 6.". Hum. Genet. 81 (1): 88–92.  
  • Vlahović P, Stefanović V (1995). "Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells.". Archives internationales de physiologie, de biochimie et de biophysique 102 (3): 171–3.  
  • Hansen KR, Resta R, Webb CF, Thompson LF (1996). "Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.". Gene 167 (1-2): 307–12.  
  • Airas L, Jalkanen S (1996). "CD73 mediates adhesion of B cells to follicular dendritic cells.". Blood 88 (5): 1755–64.  
  • Airas L, Niemelä J, Salmi M, et al. (1997). "Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells.". J. Cell Biol. 136 (2): 421–31.  
  • Strohmeier GR, Lencer WI, Patapoff TW, et al. (1997). "Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.". J. Clin. Invest. 99 (11): 2588–601.  
  • Aumüller G, Renneberg H, Schiemann PJ, et al. (1998). "The role of apocrine released proteins in the post-testicular regulation of human sperm function.". Adv. Exp. Med. Biol. 424: 193–219.  
  • Rosi F, Agostinho AB, Carlucci F, et al. (1998). "Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase.". Life Sci. 62 (25): 2257–66.  

Further reading

  1. ^ Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". Eur. J. Biochem. 191 (3): 563–9.  
  2. ^ "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)". 
  3. ^ St. Hilaire, Cynthia; Ziegler, Shira G.; Markello, Thomas C.; Brusco, Alfredo; Groden, Catherine; Gill, Fred; Carlson-Donohoe, Hannah; Lederman, Robert J.; Chen, Marcus Y.; Yang, Dan; Siegenthaler, Michael P.; Arduino, Carlo; Mancini, Cecilia; Freudenthal, Bernard; Stanescu, Horia C.; Zdebik, Anselm A.; Chaganti, R. Krishna; Nussbaum, Robert L.; Kleta, Robert; Gahl, William A.; Boehm, Manfred (2011). "NT5EMutations and Arterial Calcifications". New England Journal of Medicine 364 (5): 432–442.  
  4. ^ Sharp, J. (March 1954). "Heredo-familial vascular and articular calcification". Ann. Rheum. Dis. 13 (1): 15–27.  
  5. ^ Online 'Mendelian Inheritance in Man' (OMIM) 211800


See also

[5][4][3] reducing circulation in the legs and the joints of the hands and feet causing pain.tibial arteries, and femoral, iliac (CALJA) affecting the calcification of joints and arteries are associated with a syndrome of adult-onset allelic variants Rare [2]

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