World Library  
Flag as Inappropriate
Email this Article

Nt5e

Article Id: WHEBN0014755145
Reproduction Date:

Title: Nt5e  
Author: World Heritage Encyclopedia
Language: English
Subject: CD1A, CD153, CD320, NKG2, CD109
Collection: Clusters of Differentiation
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Nt5e

5'-nucleotidase, ecto (CD73)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CALJA; CD73; E5NT; NT; NT5; NTE; eN; eNT
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (Cluster of Differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.[1] CD73 commonly serves to convert AMP to adenosine.

Contents

  • Function 1
  • See also 2
  • References 3
  • Further reading 4
  • External links 5

Function

Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

  • Resta R, Thompson LF (1997). "T cell signalling through CD73.". Cell. Signal. 9 (2): 131–9.  
  • Kirchhoff C, Hale G (1997). "Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.". Mol. Hum. Reprod. 2 (3): 177–84.  
  • Resta R, Yamashita Y, Thompson LF (1998). "Ecto-enzyme and signaling functions of lymphocyte CD73.". Immunol. Rev. 161: 95–109.  
  • Rosi F, Carlucci F, Marinello E, Tabucchi A (2002). "Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia.". Biomed. Pharmacother. 56 (2): 100–4.  
  • Babiychuk EB, Draeger A (2006). "Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?". Biochem. Soc. Trans. 34 (Pt 3): 374–6.  
  • Stefanovic V, Mandel P, Rosenberg A (1976). "Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells.". J. Biol. Chem. 251 (13): 3900–5.  
  • Thomson LF, Ruedi JM, Glass A, et al. (1990). "Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73).". Tissue Antigens 35 (1): 9–19.  
  • Klemens MR, Sherman WR, Holmberg NJ, et al. (1990). "Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.". Biochem. Biophys. Res. Commun. 172 (3): 1371–7.  
  • Boyle JM, Hey Y, Guerts van Kessel A, Fox M (1989). "Assignment of ecto-5'-nucleotidase to human chromosome 6.". Hum. Genet. 81 (1): 88–92.  
  • Vlahović P, Stefanović V (1995). "Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells.". Archives internationales de physiologie, de biochimie et de biophysique 102 (3): 171–3.  
  • Hansen KR, Resta R, Webb CF, Thompson LF (1996). "Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.". Gene 167 (1-2): 307–12.  
  • Airas L, Jalkanen S (1996). "CD73 mediates adhesion of B cells to follicular dendritic cells.". Blood 88 (5): 1755–64.  
  • Airas L, Niemelä J, Salmi M, et al. (1997). "Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells.". J. Cell Biol. 136 (2): 421–31.  
  • Strohmeier GR, Lencer WI, Patapoff TW, et al. (1997). "Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.". J. Clin. Invest. 99 (11): 2588–601.  
  • Aumüller G, Renneberg H, Schiemann PJ, et al. (1998). "The role of apocrine released proteins in the post-testicular regulation of human sperm function.". Adv. Exp. Med. Biol. 424: 193–219.  
  • Rosi F, Agostinho AB, Carlucci F, et al. (1998). "Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase.". Life Sci. 62 (25): 2257–66.  

Further reading

  1. ^ Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". Eur. J. Biochem. 191 (3): 563–9.  
  2. ^ "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)". 
  3. ^ St. Hilaire, Cynthia; Ziegler, Shira G.; Markello, Thomas C.; Brusco, Alfredo; Groden, Catherine; Gill, Fred; Carlson-Donohoe, Hannah; Lederman, Robert J.; Chen, Marcus Y.; Yang, Dan; Siegenthaler, Michael P.; Arduino, Carlo; Mancini, Cecilia; Freudenthal, Bernard; Stanescu, Horia C.; Zdebik, Anselm A.; Chaganti, R. Krishna; Nussbaum, Robert L.; Kleta, Robert; Gahl, William A.; Boehm, Manfred (2011). "NT5EMutations and Arterial Calcifications". New England Journal of Medicine 364 (5): 432–442.  
  4. ^ Sharp, J. (March 1954). "Heredo-familial vascular and articular calcification". Ann. Rheum. Dis. 13 (1): 15–27.  
  5. ^ Online 'Mendelian Inheritance in Man' (OMIM) 211800

References

See also

[5][4][3] reducing circulation in the legs and the joints of the hands and feet causing pain.tibial arteries, and femoral, iliac (CALJA) affecting the calcification of joints and arteries are associated with a syndrome of adult-onset allelic variants Rare [2]

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.