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Nur (biology)

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Nur (biology)

Nur (nuclear receptor subfamily 4) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance. Recently, members of the NR4A family have been implicated in the control of skeletal muscle metabolism.[1][2]

Three members have been identified in humans:[3][4]

References

  1. ^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27.  
  2. ^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65.  
  3. ^ Maxwell MA, Muscat GE (2006). "The NR4A subgroup: immediate early response genes with pleiotropic physiological roles". Nucl Recept Signal 4: e002.  
  4. ^ Maheux J, Ethier I, Rouillard C, Lévesque D (2005). "Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action". J. Pharmacol. Exp. Ther. 313 (1): 460–73.  


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