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Prkab2

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Prkab2

Protein kinase, AMP-activated, beta 2 non-catalytic subunit
PDB rendering based on 2f15.
Available structures
PDB Ortholog search: RCSB
Identifiers
PRKAB2 Gene
RNA expression pattern

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.[1][2]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.[2]

Related gene problems

Interactions

PRKAB2 has been shown to interact with PRKAG2[3] and PRKAG1.[3]

Research on the genes CHD1L and PRKAB2 within lymphoblast cells[4] lead to the conclusion that anomalies appear with the 1q21.1-deletionsyndrome:

  • CHD1L is an enzyme which is involved in untangling the chromatides and the DNA repair system. With 1q21.1 deletion syndrome a disturbance occurs, which leads to increased DNA breaks. The role of CHD1L is similar to that of helicase with the Werner syndrome
  • PRKAB2 is involved in maintaining the energy level of cells. With 1q21.1-deletion syndrome this function was attenuated.

References

Further reading



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