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Title: Ptk6  
Author: World Heritage Encyclopedia
Language: English
Subject: Tyrosine kinase, SH2 domain, Non-receptor tyrosine kinase
Publisher: World Heritage Encyclopedia


Protein tyrosine kinase 6
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[2][3][4]


Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[4]

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[4]


PTK6 has been shown to interact with STAP2[5] and KHDRBS1.[6]


Further reading

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