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Perisinusoidal space

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Title: Perisinusoidal space  
Author: World Heritage Encyclopedia
Language: English
Subject: Intrahepatic bile ducts, Liver cytology, Erythropoietin, Sphincter of Oddi, Periportal space
Collection: Histology, Liver Anatomy
Publisher: World Heritage Encyclopedia

Perisinusoidal space

Perisinusoidal space
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
Basic liver structure
Latin spatium perisinusoideum
Code TH H3.
Anatomical terminology

The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium, as well as its basement membrane,[1] facilitates this transport.[2] This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).

The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A). A variety of insults that cause inflammation can result in Ito cells transforming to myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis.

The Space of Disse was named after German anatomist Joseph Disse (1852–1912).[3]


  1. ^ Mescher, Anthony L. "The Circulatory System." Junquiera's Basic Histology. 12th Ed. New York: McGraw-Hill, 2010. Print. 197.
  2. ^ Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders.  
  3. ^ Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684.  

External links

  • UIUC Histology Subject 1317
  • Histology image: 22103loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
  • Histology image: 15204loa – Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
  • Anatomy photo: digestive/mammal/liver5/liver7 - Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)"

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