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Persin

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Persin

For an island in Bulgaria, see Persin Island
Persin
Identifiers
CAS number  YesY
PubChem
Jmol-3D images Image 1
Properties
Molecular formula C23H40O4
Molar mass 380.56 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Persin is a fungicidal toxin present in the avocado.[1] It is generally harmless to humans, but when consumed by domestic animals in large quantities it is dangerous.[2]

Persin is an oil-soluble compound structurally similar to a fatty acid, and it leaches into the body of the fruit from the pits. Negative effects in humans seem to be primarily in allergic individuals.

Pathology

Consumption of the leaves and bark of the avocado tree, or the skin and pit of the avocado fruit have been shown to have the following effects:[2]

  • In birds (which are particularly sensitive to the avocado toxin), the symptoms are: increased heart rate, myocardial tissue damage, labored breathing, disordered plumage, unrest, weakness, and apathy. High doses cause acute respiratory syndrome (asphyxia), with death approximately 12 to 24 hours after consumption.
  • Lactating rabbits and mice: non-infectious mastitis and agalactia after consumption of leaves or bark.
  • Rabbits: cardial arrhythmia, submandibular edema and death after consumption of leaves.
  • Cows and goats: mastitis, decreased milk production after consumption of leaves or bark.
  • Horses: Clinical effects occur mainly in mares, and includes noninfectious mastitis, as well as occasional gastritis and colic.
  • Cats, Dogs: vomiting, diarrhea.
  • Hares, pigs, rats, sheep, ostriches, chickens, turkeys and fish: symptoms of intoxication similar those described above. The lethal dose is not known; the effect is different depending upon the animal species.[3]

Additional pharmacology

Animal studies show that exposure to persin leads to apoptosis in certain types of breast cancer cells.[4] It has also been shown to enhance the cytotoxic effect of tamoxifen in vitro.[5] Persin is however highly insoluble in aqueous solutions and more research will be needed to put it into a soluble tablet form.[5]

References

  1. ^ Oelrichs PB, Ng JC, Seawright AA, Ward A, Schäffeler L, MacLeod JK (1995). "Isolation and identification of a compound from avocado (Persea americana) leaves which causes necrosis of the acinar epithelium of the lactating mammary gland and the myocardium". Nat. Toxins 3 (5): 344–9.  
  2. ^ a b ASPCA Poison Control: Avocado
  3. ^ Clipsham, R. "Avocado Toxicity". Retrieved 2010-04-28. 
  4. ^ Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, MacLeod JK, Liaw TYE, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK and Sutherland RL (2006). activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells"in vivo"A novel plant toxin, persin, with . Mol Cancer Ther 5 (9): 2300–9.  
  5. ^ a b Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ (October 2007). "Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism". Mol. Cancer Ther. 6 (10): 2777–85.  
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