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Phosphatidylcholine synthase

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Title: Phosphatidylcholine synthase  
Author: World Heritage Encyclopedia
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Subject: Kinases, RNA polymerase IV, RNase PH, Diphosphotransferase, Class II PI 3-kinases
Collection: Ec 2.7.8, Enzymes of Unknown Structure
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Phosphatidylcholine synthase

phosphatidylcholine synthase
Identifiers
EC number 2.7.8.24
CAS number 243666-86-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + choline \rightleftharpoons CMP + phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline, whereas its two products are CMP and phosphatidylcholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:choline O-phosphatidyltransferase. This enzyme is also called CDP-diglyceride-choline O-phosphatidyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

  • de Rudder KE, Sohlenkamp C, Geiger O (1999). "Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase". J. Biol. Chem. 274 (28): 20011–6.  
  • Sohlenkamp C, de Rudder KE, Rohrs V, Lopez-Lara IM, Geiger O (2000). "Cloning and characterization of the gene for phosphatidylcholine synthase". J. Biol. Chem. 275 (25): 18919–25.  
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