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Prolactin receptor

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Prolactin receptor

prolactin receptor
Identifiers
Symbol PRLR
Entrez 5618
HUGO 9446
OMIM 176761
PDB 1RW5 (RCSB PDB PDBe PDBj)
RefSeq NM_000949
UniProt P16471
Other data
Locus Chr. 5 p13-p12

The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.

Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.

The receptor is a cytokine receptor,[1] and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,[2][3] Ras-Raf-MAPK, and PI-3K.[4]

There may be variation among different tissue prolactin receptors.[5]

References

  1. ^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
  2. ^ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
  3. ^ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
  4. ^ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
  5. ^ Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.

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