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Psychotridine

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Psychotridine

Psychotridine
Systematic (IUPAC) name
3-methyl-5,8b-bis[3-methyl-5-(3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl)-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl]-1,2,3a,4-tetrahydropyrrolo[2,3-b]indole
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
Chemical data
Formula C55H62N10 
Mol. mass 863.15 g/mol

Psychotridine is an alkaloid found in some species of the Psychotria genus, namely Psychotria colorata,[1] but also Psychotria forsteriana,[2] Psychotria lyciiflora,[3] Psychotria oleoides,[3] and Psychotria beccarioides.[4] Psychotridine has analgesic effects and dose-dependently inhibits dizocilpine binding to cortical membranes in vitro, suggesting that it acts as a non-competitive NMDA receptor antagonist.[1]

See also

References

  1. ^ a b Amador TA, Verotta L, Nunes DS, Elisabetsky E (May 2001). "Involvement of NMDA receptors in the analgesic properties of psychotridine". Phytomedicine : International Journal of Phytotherapy and Phytopharmacology 8 (3): 202–6.  
  2. ^ Beretz A, Roth-Georger A, Corre G, Kuballa B, Anton R, Cazenave JP (August 1985). "Polyindolinic Alkaloids from Psychotria forsteriana. Potent Inhibitors of the Aggregation of Human Platelets". Planta Medica 51 (4): 300–3.  
  3. ^ a b Jannic V, Guéritte F, Laprévote O, et al. (June 1999). "Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora". Journal of Natural Products 62 (6): 838–43.  
  4. ^ "Psychotridine, a C55H62N10 alkaloid from Psychotria beccarioides (Rubiaceae)". Australian Journal of Chemistry 27 (3): 639–646. 1974.  
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