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Pumiliotoxin 251D

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Pumiliotoxin 251D

Pumiliotoxin 251D
Identifiers
CAS number 73376-35-9 N
PubChem 6440480
ChemSpider 4944741 N
ChEBI CHEBI:35596 YesY
Jmol-3D images Image 1
Properties
Molecular formula C16H29NO
Molar mass 251.41 g mol−1
Hazards
Main hazards Toxic
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pumiliotoxin 251D is one of the toxins found in the skin of poison frogs from the Dendrobates, Epipedobates, Minyobates and Phyllobates[1][2] and toads from the Melanophryniscus families.[3][4] It is not manufactured by the amphibians, but absorbed through their insect-rich diet.[5][6] It is extremely toxic to mosquitoes.[7]

Pumiliotoxin 251D is a powerful toxin with several mechanisms of action, both blocking sodium and potassium channels in cells,[8] and inhibiting calcium-dependent ATPase.[9][10]

Some poison frogs have the ability to convert pumiliotoxin 251D into allopumiliotoxin 267A, a more potent variant of the toxin.[11]

References

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