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Purtscher's retinopathy

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Title: Purtscher's retinopathy  
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Purtscher's retinopathy

Purtscher's retinopathy
Classification and external resources
DiseasesDB 33929
eMedicine article/1225431

Purtscher's retinopathy is a disease where part of the eye (retina) is damaged. Usually associated with severe head injuries, it may also occur with other types of trauma, such as long bone fractures, or with several non-traumatic systemic diseases. However, the exact cause of the disease is not well understood. There are no treatments specific for Purtscher's retinopathy, and the prognosis varies. The disease can threaten vision, sometimes causing temporary or permanent blindness.

It is named for the Austrian ophthalmologist, Othmar Purtscher (1852–1927), who detected it in 1910 and described it fully in 1912.

Contents

  • History of the disease 1
  • Diagnosis 2
  • Pathophysiology 3
  • Associated diseases 4
  • Treatment 5
  • Prognosis 6
  • References 7

History of the disease

Purtscher's retinopathy was first characterized in 1910 and 1912 as a syndrome of sudden blindness after head trauma,[1] with patches of hemorrhage and whitening of the retina in both eyes.[2] Later, it was discovered to occur after other types of trauma, such as chest trauma, and is associated with several non-traumatic systemic diseases.[2] Purtscher's retinopathy may also be associated with acute pancreatitis, vasculitis, embolization of such materials as fat and amniotic fluid,[3] systemic lupus erythematosus, thrombotic thrombocytopenic purpura, and chronic renal failure.[2] Purtscher's retinopathy may be caused by extensive fractures of the long bones.[4]

Diagnosis

Where trauma is involved, only a funduscopic examination of the back of the eye (retina) is necessary to make the diagnosis.[2] Fluoroscein angiography may show a decrease in blood flow to the areas of whiteness in the retina.

Pathophysiology

Purtscher's retinopathy likely involves complex pathophysiology, with several contributing factors, including complement-mediated aggregates, fat, air, fibrin clots and platelet clumps.[5] The diseases leads to the formation of cotton wool spots in the retina, a finding observed in several other diseases, and atrophy of the optic nerve.[2]

Associated diseases

Treatment

It may be treated with triamcinolone in some cases.[6] However, in general, there are no treatments for Purtscher's retinopathy. If it is caused by a systemic disease or emboli, then those conditions should be treated.

Prognosis

Purtscher's retinopathy can lead to loss of vision,[7] and recovery of vision may occur very little.[2] However, vision recovery does occur in some cases, and reports have varied on the long-term prognosis.[8]

References

  1. ^
  2. ^ a b c d e f
  3. ^ Retinopathy, Purtscher's at eMedicine
  4. ^
  5. ^
  6. ^
  7. ^
  8. ^
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